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Cardio-Oncology Prehabilitation Program to Improve Cardiac Reserve in High-Risk Patients Undergoing Hematopoietic Stem Cell Transplantation

Primary Investigator
Leja, Monika
Status
OPEN TO ACCRUAL
Phase
NA
NCT Number
NCT05945121
UM Number
2023.004
Age Group
Adults
Management Group
CTSU - Oncology
Oncology Group
Bone Marrow Transplant
ID (Protocol)
45298
Secondary Protocol No
HUM00223835
Scope
Unspecified
Sponsor Type
Externally Peer-Reviewed
Disease Site
Hodgkin's Lymphoma
Leukemia, other
Lymphoid Leukemia
Multiple Myeloma
Myeloid and Monocytic Leukemia
Non-Hodgkin's Lymphoma
Other Hematopoietic
Summary
To assess the feasibility and preliminary effectiveness of a Cardio-Oncology Prehabilitation program in patients at high-risk of developing Cardiovascular (CV) events in improving Cardiorespiratory fitness (CRF) and reducing acute CV complications in Hematopoietic stem cell transplant (HSCT) recipients.

Eligibility: Inclusion Criteria
  •   Adult 18 years or older
  •   Referred for CV evaluation prior to HSCT
  •   Able to ambulate unassisted
  •   Ability to understand and the willingness to sign a written informed consent.
Exclusion Criteria
  •   Severe anemia (hemoglobin 7 gm/dl)
  •   Untreated high-risk coronary artery disease (left main, triple vessel disease)
  •   Severe aortic stenosis
  •   Recent fracture as assessed via self-report
  •   Gross balance deficits
  •   Severe pain with basic movement
  •   Unable to ambulate unassisted or exercise
  •   NYHA class IV heart failure
  •   Adults unable to give consent, pregnant women, and prisoners are excluded from this study.