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ALTE22C1, Chronic Health Conditions in Down Syndrome-Associated Acute Leukemia: The Down Syndrome Phenotyping Acute Leukemia Study in Survivors (DS-PALS Survivors)

Primary Investigator
Goldman, Joshua
Status
OPEN TO ACCRUAL
Phase
NA
NCT Number
NCT05702645
UM Number
2023.088
Age Group
Children
Management Group
CTSU - Oncology
Oncology Group
Childhood Cancers
ID (Protocol)
49617
Secondary Protocol No
HUM00240882
Scope
Unspecified
Sponsor Type
Institutional
Disease Site
Leukemia, other
Lymphoid Leukemia
Myeloid and Monocytic Leukemia
Summary
This study attempts to learn more about the health of persons with Down syndrome after treatment for acute leukemia. Children with Down syndrome are at increased risk for side effects during treatment for acute leukemia, but it is unclear of their risk for long-term effects of cancer treatment. By learning more about the factors that may contribute to chronic health conditions and long-term effects after treatment for leukemia in persons with Down syndrome, clinical practice guidelines for survivorship care can be developed to help improve their quality-of-life.

Eligibility: Inclusion Criteria
  •   * Patients age >= 6 and 40 years at the time of enrollment
  •   * A diagnosis of Down syndrome is required, and may include any of the three recognized types: trisomy 21 resulting from chromosomal nondisjunction (most common), translocation (the patient has 46 chromosomes, but all or part of an additional copy of chromosome 21 is attached to another chromosome), or mosaicism (trisomy 21 that is present in only a fraction of cells)
  •   * All patients must be DS-AL survivors (acute lymphoblastic leukemia [ALL] or acute myeloid leukemia [AML])
    •   * Note: Myeloid leukemia of Down syndrome (ML-DS) would be included under AML category above. Also note that survivors of relapsed disease are eligible, so long as the patient otherwise meets eligibility criteria, i.e., treatment for relapse was completed at least 36 calendar months prior to enrollment and did not include stem cell transplant
  •   * Patients must have been treated for ALL or AML
    •   * Note: History of COG therapeutic trial participation is not required. As a reminder ML-DS would be included under the AML category here above
  •   * All cancer treatment (oral or intravenous) must have been completed at least 36 calendar months prior to enrollment
  •   * Patients must have a life expectancy of > 1 year
  •   * Patient and parent of subject must be either English or Spanish speaking. At least one parent or guardian must be able to read and write in English or Spanish
    •   * Note: Parents or guardians are responsible for completing all forms, even in the case of subjects that are >= 18 years old
  •   * All patients and/or their parents or legal guardians must sign a written informed consent
  •   * All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met
Exclusion Criteria
  •   * Patients with history of hematopoietic stem cell transplant (HSCT) are excluded
    •   * Note: Patients with previous chimeric antigen receptor T-cell (CAR T-cell) therapy, and other cellular cancer therapies can participate, as long as all other eligibility criteria are satisfied
  •   * Patients with a history of cancers prior to their ALL or AML diagnosis are excluded. Patients that developed a subsequent malignant neoplasm following their ALL or AML diagnosis are also excluded
    •   * Note: Prior history of transient abnormal myelopoiesis is allowed, but is not sufficient for eligibility
  •   * Patients whose parents or guardians are unable to complete the required forms are excluded